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Medical Author: Melissa Conrad Stöppler, MD Medical Editor: William C.
D., a postdoctoral researcher in the laboratory of CSHL Professor David Tuveson, M. D., looked closely at cells sampled from 308 people with pancreatic cancer, one of the most lethal malignancies, with a 5-year survival rate of only 8%. This enabled Feigin and colleagues including computational biologist Tyler Garvin, Ph.
D., formerly of Adjunct Associate Professor Michael Schatz's lab, to focus narrowly on genome segments called gene promoters.
lie adjacent to, but not within, the sequences of the genes that they regulate.
Therefore, promoters are "invisible" when only the exomes of cells are sequenced, as has been commonplace in cancer genetics research.